Cancer Heterogeneity and Plasticity

ISSN 2818-7792
Free Publication in 2025

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About This Journal
Cancer Heterogeneity and Plasticity (ISSN 2818-7792) is an international, peer-reviewed, Open Access (OA) journal dedicated to showcasing outstanding original research articles, reviews, and perspectives spanning the dynamic realm of cancer cell heterogeneity and adaptability and the complexities within their microenvironments. Its scope encompasses a wide spectrum of topics, including but not limited to the elucidation of evolutionary relationship of cancer cell subpopulations (i.e., heterogeneity), molecular mechanisms driving cancer cell plasticity (e.g., epithelial-mesenchymal transition or EMT), epigenetic underpinnings of cancer cell reprogramming (e.g., treatment-induced neuroendocrine (NE) transdifferentiation), and the influence of the tumor microenvironment (TME) on cancer cell dynamics. It extends to embrace studies exploring the impact of the microenvironment and systemic host factors (e.g., hormones, growth factors, inflammatory cytokines, and nerves) on cancer progression, therapeutic resistance, cancer cell dissemination and dormancy, metastasis, and the development of innovative targeted and combinatorial therapies.
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About Editor-in-Chief
Dean G. Tang

Professor and Chair, Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center (RPCCC), USA

Dean Tang, PhD, is currently Distinguished Professor and Chair of Department of Pharmacology & Therapeutics at the Roswell Park Comprehensive Cancer Center in Buffalo, NY. He also holds the George Decker Endowed Chair in Developmental Therapeutics. Trained as a Pathologist, Dr. Tang obtained his PhD in Cancer Biology in 1994 from Wayne State University (Detroit, MI, USA). In 1998-2000, Dean pursued a Burroughs-Wellcome senior post-doctoral fellowship with Dr. Martin Raff at the MRC LMCB (University College London, UK) studying stem/progenitor cell development and plasticity. In June 2000, Dr. Tang joined the University of Texas M.D Anderson Cancer Center as a faculty member. After working at the M.D Anderson for 16 years, Dr. Tang was recruited to Roswell Park in June of 2016 to Chair the Department of Pharmacology & Therapeutics and Co-Lead the CCSG Developmental Therapeutic (DT) Program. He’s also the Chair of the Experimental Therapeutic (ET) Graduate Program. 
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Latest Articles
Commentary

Luminal Transcription Factor Hierarchy Shapes the AR Cistrome in Prostate Cancer

Ishana Lodhia, Amina Zoubeidi

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2502020009

Received: May 7, 2025 | Accepted: May 12, 2025 | Published: May 22, 2025
Original Research

A Hierarchy of Luminal Transcription Factors Defines AR Cistrome and Is Lost in Neuroendocrine Prostate Cancer

Viriya Keo, Xiaodong Lu, Lourdes Brea, Xianglin Shi, Jindan Yu, Jonathan C. Zhao

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2502020008

Received: Dec 6, 2024 | Accepted: Apr 16, 2025 | Published: May 6, 2025
Original Research

Combined Transcriptomic and Epitranscriptomic Profiling Identifies THBS1 as A Regulator of Enzalutamide Resistance in Prostate Cancer

Emmanuelle Hodara, Lisa Swartz, Aubree Mades, Daniel Bsteh, Tong Xu, Suhn K. Rhie, Amir Goldkorn

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2502020007

Received: Dec 14, 2024 | Accepted: Apr 3, 2025 | Published: Apr 21, 2025
Review

Lipid Metabolism and Immune Response in Hepatocellular Carcinoma: Interplay Driving Tumor Progression

Tiffany Ching-Yun Yu, Yu-Man Tsui, Vanilla Xin Zhang, Huanhuan Ma, Irene Oi-Lin Ng

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2502020006

Received: Dec 6, 2024 | Accepted: Mar 25, 2025 | Published: Apr 4, 2025
Review

Molecular Characteristics, Heterogeneity, Plasticity, and Cell of Origin of Neuroendocrine Bladder Cancer

Dongbo Xu, Qiang Li

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2502010005

Received: Nov 28, 2024 | Accepted: Feb 27, 2025 | Published: Mar 6, 2025
Review

Breast Cancer Stem Cell Heterogeneity, Plasticity and Treatment Strategies

Mengting Chen, Suling Liu

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2502010004

Received: Nov 29, 2024 | Accepted: Feb 26, 2025 | Published: Mar 6, 2025
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