Cancer Heterogeneity and Plasticity

Free Publication in 2024

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About This Journal
Cancer Heterogeneity and Plasticity is an international, peer-reviewed, Open Access (OA) journal dedicated to showcasing outstanding original research articles, reviews, and perspectives spanning the dynamic realm of cancer cell heterogeneity and adaptability and the complexities within their microenvironments. Its scope encompasses a wide spectrum of topics, including but not limited to the elucidation of evolutionary relationship of cancer cell subpopulations (i.e., heterogeneity), molecular mechanisms driving cancer cell plasticity (e.g., epithelial-mesenchymal transition or EMT), epigenetic underpinnings of cancer cell reprogramming (e.g., treatment-induced neuroendocrine (NE) transdifferentiation), and the influence of the tumor microenvironment (TME) on cancer cell dynamics. It extends to embrace studies exploring the impact of the microenvironment and systemic host factors (e.g., hormones, growth factors, inflammatory cytokines, and nerves) on cancer progression, therapeutic resistance, cancer cell dissemination and dormancy, metastasis, and the development of innovative targeted and combinatorial therapies.
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About Editor-in-Chief
Dean Tang

Professor and Chair, Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center (RPCCC), USA

Dean G. Tang is currently Professor and Chair of Department of Pharmacology & Therapeutics at the Roswell Park Comprehensive Cancer Center in Buffalo, NY. He also holds the George Decker Endowed Chair in Developmental Therapeutics. Trained as a Pathologist, Dr. Tang obtained his PhD in Cancer Biology in 1994 from Wayne State University (Detroit, MI, USA). In 1998-2000, Dean pursued a Burroughs-Wellcome senior post-doctoral fellowship with Dr. Martin Raff at the MRC LMCB (University College London, UK) studying stem/progenitor cell development and plasticity. In June 2000, Dr. Tang joined the University of Texas M.D Anderson Cancer Center as a faculty member. After working at the M.D Anderson for 16 years, Dr. Tang was recruited to Roswell Park in June of 2016 to Chair the Department of Pharmacology & Therapeutics and Co-Lead the CCSG Developmental Therapeutic (DT) Program. He's also the Chair of the Experimental Therapeutic (ET) Graduate Program.
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Latest Articles
Perspective

Treatment-induced stemness and lineage plasticity in driving prostate cancer therapy resistance

Anmbreen Jamroze, Xiaozhuo Liu, Dean G. Tang

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2401010005

Received: Apr 12, 2024 | Accepted: Jul 26, 2024 | Published: Aug 25, 2024
Review

Advances in Single-Cell Techniques for Linking Phenotypes to Genotypes

Hsiao-Chun Chen, Yushu Ma, Jinxiong Cheng, Yu-Chih Chen

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2401010004

Received: Jun 16, 2024 | Accepted: Jul 16, 2024 | Published: Jul 25, 2024
Original Research

Metastatic colorectal cancer cells upregulate SMLR1 that interacts with tumor-associated macrophages in the liver

Chi Wut Wong, Lihua Wang, Jorge Prado Balcazar, Yong Chen, Xiling Shen

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2401010003

Received: Mar 30, 2024 | Accepted: Jun 10, 2024 | Published: Jul 18, 2024
Commentary

Unmasking SMLR1: The hidden player in colorectal cancer's liver metastasis

Xiaozhuo Liu

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2401010002

Received: Jun 10, 2024 | Accepted: Jun 13, 2024 | Published: Jul 18, 2024
Editorial

Cancer Heterogeneity and Plasticity — A new journal dedicated to understanding cancer cell states and interactions with the tumor microenvironment

Dean G. Tang

Cancer Heterogeneity and Plasticity https://doi.org/10.47248/chp2401010001

Received: Jun 19, 2024 | Accepted: Jun 19, 2024 | Published: Jul 18, 2024
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