Cancer Heterogeneity and Plasticity is an international, peer-reviewed, Open Access (OA) journal dedicated to showcasing outstanding original research articles, reviews, and perspectives spanning the dynamic realm of cancer cell heterogeneity and adaptability and the complexities within their microenvironments. Its scope encompasses a wide spectrum of topics, including but not limited to the elucidation of evolutionary relationship of cancer cell subpopulations (i.e., heterogeneity), molecular mechanisms driving cancer cell plasticity (e.g., epithelial-mesenchymal transition or EMT), epigenetic underpinnings of cancer cell reprogramming (e.g., treatment-induced neuroendocrine (NE) transdifferentiation), and the influence of the tumor microenvironment (TME) on cancer cell dynamics. It extends to embrace studies exploring the impact of the microenvironment and systemic host factors (e.g., hormones, growth factors, inflammatory cytokines, and nerves) on cancer progression, therapeutic resistance, cancer cell dissemination and dormancy, metastasis, and the development of innovative targeted and combinatorial therapies.
Cancer Heterogeneity and Plasticity welcomes contributions from various disciplines including cancer, cell, molecular and systems biology; genetics, clinical oncology, bioinformatics, immunology, tumor imaging, and artificial intelligence (AI). For research papers, we are especially interested in studies that employ and integrate state-of-the-art experimental models (e.g., lineage tracing in mice, organoids), cutting-edge techniques (e.g., cellular bar-coding, single-cell Omics, high-content and quantitative imaging analysis, spatial transcriptomics/proteomics/pathology, CRISPR screening), and utilization of human cancer specimens (archived or live human tumor samples, PDX, CTCs, ctDNA, etc.) to elucidate cancer cell heterogeneity and plasticity. Additionally, contributions shedding light on translating these findings into clinical applications, such as prognostic markers, personalized medicine, and novel intervention strategies, are also highly encouraged.
While brevity is encouraged, there are no restrictions on the length of submissions, number of figures, or tables. Both black & white and color figures are accepted, ensuring a comprehensive and visually enriching presentation of research findings.
The journal strives to serve as a conduit for the dissemination of high-quality and rigorous research and clinical findings in cancer heterogeneity and plasticity, fostering a vibrant exchange of ideas and knowledge among researchers and practitioners in the field. Through the publication of comprehensive studies addressing fundamental scientific inquiries and practical applications, Cancer Heterogeneity and Plasticity endeavors to push the boundaries in cancer research, aiming to pave the way for enhanced diagnostics, treatments, and patient outcomes.
We adopt the Creative Commons Attribution 4.0 International License (CC BY 4.0), which means all papers published in Cancer Heterogeneity and Plasticity are freely available online. Copyright of the published papers is retained by authors. Authors grant any third party the right to use the published paper freely as long as its integrity is maintained and its original authors, citation details and publisher are correctly cited. Authors also grant Pivot Science Publications Corporation an exclusive right to publish their paper and identify it as the original publisher.
A note as below will be inserted in each paper published in Cancer Heterogeneity and Plasticity:
© Year by the author(s). This is an Open Access article distributed under the terms of the Creative Commons License Attribution 4.0 International (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is correctly credited.
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