Luminal Transcription Factor Hierarchy Shapes the AR Cistrome in Prostate Cancer

Ishana Lodhia; Amina Zoubeidi

doi:10.47248/chp2502020009

Cancer Heterogeneity and Plasticity 2025;2(2):0009 | https://doi.org/10.47248/chp2502020009

Commentary Open Access

Luminal Transcription Factor Hierarchy Shapes the AR Cistrome in Prostate Cancer

Ishana Lodhia , Amina Zoubeidi

Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada

Correspondence: Amina Zoubeidi

Academic Editor(s): Dean G. Tang

Received: May 7, 2025 | Accepted: May 12, 2025 | Published: May 22, 2025

Cite this article: Lodhia I, Zoubeidi A. Luminal Transcription Factor Hierarchy Shapes the AR Cistrome in Prostate Cancer. Cancer Heterog Plast 2025; 2(2):0009. https://doi.org/10.47248/chp2502020009

Abstract

The recruitment of the androgen receptor to lineage-defining enhancers depends on the cooperation of several luminal transcription factors to facilitate opening of the chromatin; however, their pioneer function has not been fully described. In this manuscript, Keo et al. showed that FOXA1 alone pioneers androgen receptor recruitment while HOXB13 and GATA2 serve as cofactors, illustrating a hierarchical relationship between these TFs in AR pathway active prostate cancer (ARPC).

Keywords

AR, FOXA1, HOXB13, GATA2

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