Cancer Heterogeneity and Plasticity

Justin D. Lathia  PhD

Vice Chair and Associate Professor, Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, USA
Professor, Department of Molecular Medicine, School of Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, USA
Research Interests: Malignant brain tumors; glioblastoma; cancer stem cells; cell-cell communication; cell adhesion; sex differences
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Dr. Justin Lathia leads a translational cancer stem cell research laboratory and is Vice Chair and Associate Professor in the Department of Cardiovascular and Metabolic Sciences at the Lerner Research Institute, part of the Cleveland Clinic. Dr. Lathia is also the Co-Director of the Brain Tumor Research and Therapeutic Development Center of Excellence. He is also the Reza Khatib MD Professor, Leader of the Brain Tumor Initiative, and Co-Leader of the Molecular Oncology Program at the Case Comprehensive Cancer Center. Projects in the Lathia laboratory involve understanding how cancer stem cells interact with their surrounding microenvironment as well as one another with the goal of identifying unique pathways for therapeutic development. Work in the Lathia laboratory has resulted in a Phase 1 clinical trial aimed at targeting myeloid-derived suppressor cells that interact with cancer stem cells to suppress the immune system in glioblastoma.
Dr. Lathia has co-authored over 220 publications and work in his lab is currently supported by multiple National Institutes of Health grants and foundation grants. Dr. Lathia also contributes as a peer reviewer to over 140 journals, serves on the editorial board for Cell Reports, Cancer Research, and Neuro-Oncology, has served on multiple grant review panels for the National Institutes of Health and private foundations. He recently served as a co-editor for a cancer stem cell textbook. Dr. Lathia also serves as a co-organizer for the cancer stem cell meeting held in Cleveland in 2014, 2016, and 2018. At each meeting, the three-day event drew over 300 attendees from over 25 states and 15 countries.

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