Cancer Heterogeneity and Plasticity

Amir Goldkorn  MD

Professor of Medicine and Biochemistry & Molecular Medicine, Keck School of Medicine, the University of Southern California, USA
Research Interests: developing the therapeutic and biomarker potential of liquid biopsies, cancer plasticity, and telomerase

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Dr. Goldkorn is a board-certified medical oncologist and physician-scientist who is clinically subspecialized in genitourinary (GU) malignancies. Dr. Goldkorn’s laboratory is focused on developing the therapeutic and biomarker potential of liquid biopsies, cancer plasticity, and telomerase. His team leads liquid biopsy studies in phase III multi-center GU cancer trials sponsored by the NCI-SWOG cooperative group, where Dr. Goldkorn chairs translational medicine for prostate cancer. Dr. Goldkorn founded and directs a Liquid Biopsy Core at USC’s Norris Comprehensive Cancer Center, which offers state-of-the-art instrumentation and develops novel workflows for multiparametric analysis of liquid biopsies. He also serves as Associate Director for Translational Research at Norris. In the area of cancer plasticity, Dr. Goldkorn’s group discovered that cancer cells can cyclically lose and regain cancer stem-like properties, and their current work is focused on elucidating epigenetic, epitranscriptomic, and metabolomic mechanisms that mediate this plasticity. Collectively, these research efforts are aimed at surmounting cancer heterogeneity and providing powerful new tools for precision cancer care.

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