Cancer Heterogeneity and Plasticity ISSN 2818-7792
Cancer Heterogeneity and Plasticity 2024;1(1):0006 | https://doi.org/10.47248/chp2401010006
Perspective Open Access
Developing a novel therapeutic strategy against cancer stem cell heterogeneity and plasticityAcademic Editor(s): Dean Tang
Received: Jul 11, 2024 | Accepted: Sep 16, 2024 | Published: Sep 27, 2024
Cite this article: Kondo T. Developing a novel therapeutic strategy against cancer stem cell heterogeneity and plasticity. Cancer Heterog Plast 2024; 1(1):0006. https://doi.org/10.47248/chp2401010006
Cancer consists of heterogeneous cells, including cancer stem cells (CSCs), cancer cells, and tumor-associated cells, such as immune cells and vascular cells. Considering that these diverse cell types influence one another directly and indirectly through membrane proteins and secretion factors, such as exosomes and growth factors, the overall heterogeneity affects tumorigenicity and resistance to therapy. This review explores cancer heterogeneity, focusing on CSC heterogeneity, and discussed how the heterogeneity emerges by the intrinsic mechanism and the external factors and affects response to therapy. Additionally, as a potential therapeutic strategy to address this heterogeneity, I propose new Adeno-associated virus carrying a miRNA-dependent CSC eradication system that targets all types of CSCs with minimizing side effects.
KeywordsGlioblasoma (GBM), GBM-initiating cells (GICs), heterogeneity, stem cell factors, microRNA (miR), Adeno-Associated virus (AAV)
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