Transcription factor AP-4 (TFAP4) unleashes telomerase reverse transcriptase (TERT) activity in non-viral-associated liver cancers

Paige Eversole; Sayan Chakraborty

doi:10.47248/chp2401020009

Cancer Heterogeneity and Plasticity 2024;1(2):0009 | https://doi.org/10.47248/chp2401020009

Commentary Open Access

Transcription factor AP-4 (TFAP4) unleashes telomerase reverse transcriptase (TERT) activity in non-viral-associated liver cancers

Paige Eversole ¹ , Sayan Chakraborty ²

1. Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA
2. Program of Developmental Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA

Correspondence: Sayan Chakraborty

Academic Editor(s): Dean G. Tang

Received: Nov 27, 2024 | Accepted: Nov 27, 2024 | Published: Dec 2, 2024

Cite this article: Eversole P, Chakraborty S. Transcription factor AP-4 (TFAP4) unleashes telomerase reverse transcriptase (TERT) activity in non-viral-associated liver cancers. Cancer Heterog Plast 2024; 1(2):0009. https://doi.org/10.47248/chp2401020009

Abstract

The mechanisms of transcription factors reactivating TERT in cancers is an active area of research. In this issue, Lim et al., identified TFAP4 directly interacts with TERT causing its reactivation in non-viral-associated liver cancers cell lines, thus uncovering a previously undisclosed function of TFAP-4 in telomere rewiring in liver cancers.

Keywords

TERT, TFAP4, HCC, Telomeres

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