This is a reprint of the Special Issue “Luca Cavalli-Sforza’s Legacy, 100 Years After His Birth” published by the journal Human Population Genetics and Genomics (ISSN 2770-5005).

1. Luca Cavalli-Sforza, 100 years after his birth
Lounès Chikhi, Guido Barbujani

2. LUCA, as our father
Matteo Cavalli-Sforza, Francesco Cavalli-Sforza, Luca Tommaso Cavalli-Sforza, Violetta Cavalli-Sforza

3. Cultural versus biological inheritance: A retrospective view of Cavalli-Sforza and Feldman (1973)
Hao Shen, Marcus W. Feldman

4. Revisiting the demographic history of Central African populations from a genetic perspective
Gwenna Breton, Cesar Fortes-Lima, Carina M. Schlebusch

5. Neolithic demic diffusion
Guido Barbujani

6. A genetic history of migration, diversification, and admixture in Asia
Melinda A. Yang

7. Genetics and population history. The case of the Iberian Peninsula and the "origin" of Basques
Jaume Bertranpetit

8. Prehistoric spread rates and genetic clines
Joaquim Fort

9. Luca Cavalli-Sforza and phylogenetic evolutionary methods
Joseph Felsenstein

10. Twenty years of the Human Genome Diversity Project
Serena Aneli, Giovanni Birolo, Giuseppe Matullo

11. Luigi Luca Cavalli Sforza and the history of human languages: A linguist’s point of view
Giuseppe Longobardi