This is a reprint of the Volume 1 (2024) to Issue 1, Volume 2 (2025) published by the journal Cancer Heterogeneity and Plasticity (ISSN 2818-7792).

1. Cancer Heterogeneity and Plasticity — A new journal dedicated to understanding cancer cell states and interactions with the tumor microenvironment
Dean G. Tang

2. Unmasking SMLR1: The hidden player in colorectal cancer's liver metastasis
Xiaozhuo Liu

3. Metastatic colorectal cancer cells upregulate SMLR1 that interacts with tumor-associated macrophages in the liver
Chi Wut Wong, Lihua Wang, Jorge Prado Balcazar, Yong Chen, Xiling Shen

4. Advances in Single-Cell Techniques for Linking Phenotypes to Genotypes
Hsiao-Chun Chen, Yushu Ma, Jinxiong Cheng, Yu-Chih Chen

5. Treatment-induced stemness and lineage plasticity in driving prostate cancer therapy resistance
Anmbreen Jamroze, Xiaozhuo Liu, Dean G. Tang

6. Developing a novel therapeutic strategy against cancer stem cell heterogeneity and plasticity
Toru Kondo

7. Function of noncoding RNA in regulating cancer cell plasticity
Peter Hyunwuk Her, Magnus Lam, Sarah Zeng, Housheng Hansen He

8. Transcription factor AP-4 reactivates telomerase reverse transcriptase independently of genome alteration in non-HBV associated hepatocellular carcinoma
Huiju Lim, Trevor Kwan-Hung Wu, Eliana Mary Senires Suarez, Tiffany Ching-Yun Yu, Joyce Man-Fong Lee, Yu-Man Tsui, Daniel Wai-Hung Ho, Karen Man-Fong Sze, Irene Oi-Lin Ng

9. Transcription factor AP-4 (TFAP4) unleashes telomerase reverse transcriptase (TERT) activity in non-viral-associated liver cancers
Paige Eversole, Sayan Chakraborty

10. The molecular determinants of phenotypic plasticity in homeostasis and neoplasia
Bradley Balk, David W. Goodrich

11. Heterogeneity of tumor biophysical properties and their potential role as prognostic markers
Anja Madleine Markl, Daniel Nieder, Diana Isabel Sandoval-Bojorquez, Anna Taubenberger, Jean-François Berret, Artur Yakimovich, Eduardo Sergio Oliveros-Mata, Larysa Baraban, Anna Dubrovska

12. Cancer Heterogeneity and Plasticity: 2024 in Review
Dean Tang

13. Molecular mechanisms driving lineage plasticity in prostate cancer: NANOG and beyond
Hamed Maasoumyhaghighi, Mansoureh Nouri, Jinghui Liu, Xiaoqi Liu

14. Astrocyte plasticity shapes brain metastasis progression through tumor-astrocyte crosstalk
Rupleen Kaur, Nalin Gupta, Andrew Dhawan

15. DIAPH3 in Cancer: Role and Mechanism
Jiangling Xiong, Lanxin Hu, Jinwei Zhu, Lianlian Yan, Yuqing Feng, Cheng Zou, Yang Mei, Dinglan Wu, Dingxiao Zhang

16. Breast Cancer Stem Cell Heterogeneity, Plasticity and Treatment Strategies
Mengting Chen, Suling Liu

17. Molecular Characteristics, Heterogeneity, Plasticity, and Cell of Origin of Neuroendocrine Bladder Cancer
Dongbo Xu, Qiang Li